Redington Life Sciences News

Special Issue June 2021

In this issue: origins of the human smile, UCLA parses the ‘language’ of immune cells, fatal lung cancer decisions, living up to 150 years, rise early to limit depression risks, Yale on suicide and dementia, reclassifying Alzheimer’s, Mayo on kidney stones, belly weight and the heart, and more…


New study sheds light on the deep evolutionary origins of the human smile

The origins of a pretty smile have long been sought in the fearsome jaws of living sharks which have been considered living fossils reflecting the ancestral condition for vertebrate tooth development and inference of its evolution. However, this view ignores real fossils which more accurately reflect the nature of ancient ancestors.

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UCLA scientists decode the ‘language’ of immune cells

The advance, researchers say, is like the cellular equivalent of discovering the Rosetta stone and may eventually lead to new treatments for diseases.

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Checkpoint Therapeutics Announces Completion of Enrollment in the Registration-Enabling Trial of Cosibelimab in Metastatic Cutaneous Squamous Cell Carcinoma

Top-line results expected in 4Q 2021
Targeting BLA submission in 1H 2022
Market-disruptive pricing planned in $25 billion and growing PD-(L)1 market

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Delaying lung cancer surgery associated with higher risk of recurrence, death

Swiftness is essential when treating lung cancer, the second most common type of cancer in the U.S. and the country’s leading cause of cancer deaths. For patients with early-stage non-small cell lung cancer, surgical removal of a tumor-infested lung or of a smaller lung section may be the only treatment needed.

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Humans Could Live up to 150 Years, New Research Suggests

A study counts blood cells and footsteps to predict a hard limit to our longevity

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TG Therapeutics Announces FDA Acceptance of Biologics License Application for Ublituximab in Combination with UKONIQ® (umbralisib) as a Treatment for Patients with Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma

The U.S. Food and Drug Administration (FDA) has accepted the Biologics License Application (BLA) for ublituximab, the Company’s investigational glycoengineered anti-CD20 monoclonal antibody, in combination with UKONIQ® (umbralisib), the Company’s once-daily, oral, inhibitor of PI3K-delta and CK1-epsilon, as a treatment for patients with chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL).

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Waking just one hour earlier cuts depression risk by double digits, study finds

A genetic study of 840,000 people found that shifting sleep time earlier by just an hour decreases risk of major depression by 23 percent.

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Yale study: Suicide risk higher for older adults diagnosed with dementia

Adults over age 65 who have been diagnosed with dementia are more than twice as likely to die from suicide compared to those who do not suffer from dementia.


Alzheimer’s Disease Is Not a Mental Illness

Mental health is an issue that continues to raise concern in the United States . According to an annual report by the nonprofit organization Mental Health America, incidences of anxiety and depression have reached their highest level since the pandemic began last March.

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Mayo study finds that pregnancy increases risk for women to develop first-time symptomatic kidney stones

ROCHESTER, Minn. Though researchers have long known that several physiological and anatomical changes occur during pregnancy that can contribute to kidney stone formation, evidence of the link has been lacking. But now Mayo Clinic researchers believe they have that evidence.

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More belly weight increases danger of heart disease even if BMI does not indicate obesity

Research on how obesity impacts the diagnosis, management and outcomes of heart and blood vessel disease, heart failure and arrhythmias is summarized in a new statement. Waist circumference, an indicator of abdominal obesity, should be regularly measured as it is a potential warning sign of increased cardiovascular disease risk.

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Novel gene identified as genetic cause of portal hypertension

A Yale research team has discovered the genetic root of a potentially fatal complication of the liver.

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Scientists discover brain cells that compete to sustain or suppress traumatic memories


Findings could provide important insights into human conditions such as PTSD, anxiety.


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Alcohol problems severely undertreated

Some 16 million Americans are believed to have alcohol use disorder, and an estimated 93,000 people in the U.S. die from alcohol-related causes each year. Both of those numbers are expected to grow as a result of heavier drinking during the COVID-19 pandemic.

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UVA Develops New Tools to Battle Cancer, Advance Genomics Research

A new website, bartcancer.org, can provide "unique insights" for cancer researchers, its creators say.


Key early steps in gene expression captured in real time

Scientists have observed early RNA transcription dynamics by recording where, when and how RNA polymerase enzymes kick off transcription by binding to a DNA sequence.


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Shining new light on immunotherapy for breast cancer

Research shows some breast cancer types may benefit from immunotherapy, but new trial designs are needed to evaluate this potential.


Gene therapy offers potential cure to children born without an immune system

The treatment, developed by researchers from UCLA and the UK, has restored immune function in more than 95% of patients in three clinical trials.


Research shows one size doesn’t fit all for cervical screening in the trans and non-binary community

Science blog The soft thud as once every few years a cervical screening invite lands on the doormat. A gentle reminder to book a cervical screening appointment, should it be wanted. But for transgender men or non-binary people assigned female at birth, this invite may not be automatic and getting access to this service can be much more difficult at every step of the way. "LGBTQ+ people in general

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Some RNA Molecules Have Unexpected Sugar Coating

Sugars attach to certain RNA molecules on the outside membrane of the cell. The newly discovered "glycoRNAs" may be involved in immune signaling.

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Sugar-sweetened drinks linked to increased risk of colorectal cancer in women under 50

Colorectal cancer diagnoses have increased among people under age 50 in recent years and researchers are seeking reasons why. A new study led by Washington University School of Medicine in St. Louis has found a link between drinking sugar-sweetened beverages and an increased risk of developing colorectal cancer in women under age 50.

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Common anti-inflammatory drug could boost cancer immunotherapy

Science blog Widely-used anti-inflammatory drugs make tumours in mice more responsive to treatments that harness the power of the body’s own immune system to tackle cancer, according to research funded by Cancer Research UK and published in the journal Cancer Discovery.


Rooted tree key to understanding bacterial evolution, new study suggests

An international team of researchers led by Dr Tom Williams from the University of Bristol’s School of Biological Sciences have found a new way to interpret the evolution of bacteria.

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Major Depressive Disorders Have an Enormous Economic Impact

Their prevalence has more than tripled during the pandemic, but the trends were already troubling long before it arrived.


Process for eliminating unneeded cells may also protect against cancer

Biologists find cell extrusion, a process that helps organisms eliminated unneeded cells, is triggered when cells can't replicate their DNA during cell division. In humans, extrusion may serve as a way for the body to eliminate cancerous or precancerous cells.

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Secret behind maintaining a healthy weight loss

Almost one in six people worldwide live with obesity, which may have serious health consequences. Researchers now document how to effectively achieve and maintain a healthy weight loss.

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Alzheimer’s Pathology Linked to Diet

People who followed a Mediterranean-style diet closely had less amyloid and tau pathology, increased brain volume in regions vulnerable to Alzheimer's disease, and better memory performance, a cross-sectional analysis in Germany...

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