Redington Life Sciences News

Special Issue January 2021

In this issue: Mayo on slowing vision loss, new strategy for ‘undruggable’ targets, junk DNA and the circadian clock, sorting out the complexities of ADHD, impact of exercise on disease, Yale on how sex and gender influence health, Black mens’ higher risk of prostate cancer, contactless thermometers, Dana Farber’s new breast cancer finding, Mayo argues butter vs. margarine (again?), the position of fleas on the tree of life, and more…

Delivering innovative stem cell therapy to slow vision loss

The regenerative eye scientist, Alan Marmorstein, Ph.D., is drawn to research by the need to find new cures for diseases. As an aspiring researcher, he never envisioned his investigative journey would take him down the path of testing ways to prevent or restore loss of eyesight.

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New study on circadian clock shows 'junk DNA' plays a key role in regulating rhythms

Researchers have been trying to figure out what regulates molecular circadian clocks, in search of new insights into diseases like Alzheimer's, cancer and diabetes. Until now, that research has focused on what is known as clock genes. 

Tonix Pharmaceuticals and Massachusetts General Hospital (MGH) Enter into Research Collaboration on Tonix’s Third Generation anti-CD40-Ligand Monoclonal Antibody, TNX-1500, for the Treatment and Prevention of Kidney Transplant Rejection

Expands Ongoing Research Collaboration Between Tonix and MGH Studying TNX-1500 in Heart Transplantation

TNX-1500 May Hold Potential in Treating Autoimmune Diseases Including Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis

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Chemists develop a new drug discovery strategy for 'undruggable' drug targets

A research team has developed a new drug discovery method targeting membrane proteins on live cells.

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General anesthesia and normal sleep affect brain in an amazingly similar way as consciousness fades

What happens in the brain when our conscious awareness fades during general anesthesia and normal sleep? Scientists studied this question with novel experimental designs and functional brain imaging.

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TG Therapeutics Announces Pivotal Data from the UNITY-CLL and UNITY-NHL Clinical Trials Presented at the 62nd American Society of Hematology Annual Meeting 

UNITY-CLL: U2 significantly improved progression-free survival over obinutuzumab plus chlorambucil (HR=0.54, p<0.0001) as well as ORR (p<0.001) in patients with CLL; with consistent PFS improvement across treatment naïve CLL (HR=0.48) and relapsed/refractory CLL (HR=0.60)

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A pursuit of better testing to sort out the complexities of ADHD

The introduction of computer simulation to the identification of symptoms in children with attention deficit/hyperactivity disorder (ADHD) has potential to provide an additional objective tool to gauge the presence and severity of behavioral problems, researchers suggest.

New imaging method reveals if antibiotics reach bacteria hiding in tissues

Researchers have developed a new imaging method to see where antibiotics have reached bacteria within tissues. The method could be used to help develop more effective antibiotic treatments, reducing the risk of antibiotic resistance.

Self-controlled children tend to be healthier middle-aged adults

Self-control of one's thoughts, feelings and behaviors is one of the personality traits that makes a child ready for school. And, it turns out, ready for life as well. A large study tracking 1,000 people from birth through age 45 has determined that people who had higher levels of self-control as children were aging more slowly than their peers at age 45.Full Details 

Protein involved in removing Alzheimer’s buildup linked to circadian rhythm

Immune cells known as microglia (turquoise with red dots) surround a plaque of the Alzheimer’s protein amyloid (blue). The red dots indicate that the microglia are prepared to remove the potentially damaging plaque.

Positive messages encourage safer driver behaviour than fear tactics

A new study has shown that films demonstrating responsible behaviour could lead to young drivers taking fewer risks on the road than if they only saw videos aimed at provoking fear of accidents.

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Butter or margarine: Mayo Clinic Radio Health Minute 

Butter is a dairy product, made from the milk or cream of a cow. Margarine is made from vegetable oil. They may look similar and may be used similarly for baking or cooking, but when it comes to heart health, that's where the similarities end. What's better for you?

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Contactless thermometer helps monitor student health

Using the contactless thermometer, like this one installed at a UW–Madison residence hall, requires just one person paying attention to the proximity sensor to position their forehead. Credit: University Housing When Lennon Rodgers visited the dentist in the midst of the COVID-19 pandemic, he had a moment of inspiration.

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Yale leads efforts to teach how sex and gender influence health 

Women’s Health Research at Yale and YSM are integrating findings and best practices on sex-and-gender differences into the school's curriculum.

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Study sheds light on genetic basis of Black men’s higher prostate cancer risk 

Black men are more likely than their White or Asian counterparts to have a range of genetic changes that increase their risk of developing prostate cancer, a major new study reports.

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Breast cancer study uncovers how macrophages may contribute to a therapeutic weak spot 

Breast cancer, the second most common cancer in the United States, can result from a number of cellular misregulations, such as deficiencies in the DNA-repairing breast cancer gene, BRCA.

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Brain tissue yields clues to causes of PTSD 

New research on post-traumatic stress disorder may help explain enduring mysteries about the disorder, such as why women are more susceptible to it.

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Science Saturday: The benefits of genetic testing for healthy people

More than 1 in 10 people who had predictive genomic testing? testing that looks for genetic mutations in otherwise healthy people? learned that they had a hereditary risk for a health condition and may benefit from preventive care, according to a recent study published in Mayo Clinic Proceedings.

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UVA Aims to Battle Disease by Understanding Effects of Exercise

A top exercise researcher and colleagues at the School of Medicine have launched an ambitious effort to understand the whole-body benefits of exercise so that doctors can use that information to prevent and treat disease.

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Study resolves the position of fleas on the tree of life

A study of more than 1,400 protein-coding genes of fleas has resolved one of the longest-standing mysteries in the evolution of insects, reordering their placement in the tree of life and pinpointing who their closest relatives are.

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New treatment could spare early-stage rectal cancer patients life-altering side effects 

News report A new and less invasive treatment developed by Cancer Research UK researchers is safer than standard major surgery for early-stage rectal cancer, giving patients a better quality of life with fewer life-altering side effects. Right now, standard treatment is a major operation to remove the whole rectum, even if the cancer is early stage.

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Increased meat consumption associated with symptoms of childhood asthma

Substances present in cooked meats are associated with increased wheezing in children, researchers report.

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Toxin provides clues to long-term effects of diarrhea caused by E. coli

Toxin-producing E. coli bacteria (green) attach to human intestinal cells expressing the protein CEACAM6 (red). A study from researchers at Washington University School of Medicine in St. Louis has found that a toxin produced by E. coli changes intestinal cells to benefit itself,Full Details

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