Redington Life Sciences News

Special Issue April 2021

In this issue: How teeth sense cold, new treatments for ‘silent’ stroke, Dana Farber on kidney cancer, Mayo on pregnancy and Covid-19 vaccines, new Alzheimer’s genes discovered, if you’re pregnant—exercise!, NIH on youthful cannabis use, dysfunction in a brainy node, reading minds with ultrasound, Yale on eating disorders, narcissism driven by insecurity, salt scans and cancer, can cancer develop in the heart?, and more…


Mysteries of malaria infections deepen after human trial study

Scientists have discovered that tracking malaria as it develops in humans is a powerful way to detect how the malaria parasite causes a range of infection outcomes in its host. The study, found some remarkable differences in the way individuals respond to malaria and raises fresh questions in the quest to understand and defeat the deadly disease.

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How Teeth Sense the Cold

An ion channel called TRPC5 acts as a molecular cold sensor in teeth and could serve as a new drug target for treating toothaches.

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Newly discovered node in brain could expand understanding of dysfunctional social behavior

A group of scientists have discovered a node in the brains of male mice that modulates the sounds they make in social situations. This discovery could help identify similar locations in the human brain, and potentially lead to a better understanding of social disorders.

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New genetic clues point to new treatments for ‘silent’ stroke

Researchers discovered changes to 12 genetic regions in the DNA of people who have had a lacunar stroke – a type of stroke caused by weakening of the small blood vessels deep within the brain. Over time, damage to the blood vessels and subsequent interruption to blood flow can lead to long-term disability, causing difficulty with thinking, memory, walking and ultimately dementia.


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Dana-Farber research leads to better understanding of the immune system in kidney cancer

Two Dana-Farber research papers highlight single-cell dissection of kidney tumors to identify new immunotherapy treatments and targets

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Tonix Pharmaceuticals Reports Positive COVID-19 Vaccine Efficacy Results in Non-Human Primates Vaccinated with TNX-1800 and Challenged with Live SARS-CoV-2

TNX-1800 is Based on a Proprietary Vaccine Platform Designed to Stimulate Long Term T cell ImmunityVaccine Candidate TNX-1800 Protected Both Upper and Lower Airways After Challenge with SARS-CoV-2, Suggesting an Ability to Block Forward Transmission

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Thirteen new Alzheimer's genes identified in human genome study

Prior known Alzheimer's genes have been associated with amyloid accumulation and neuroinflammation. A cutting-edge technique known as whole genome sequencing was used to identify new, rare gene variants associated with Alzheimer's disease. Findings could suggest new targets for drug development aimed at enhancing neuroplasticity and the stability of synapses.



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Mysterious 'nuclear speckle' structures inside cells enhance gene activity, may help block cancers

Scientists has illuminated the functions of mysterious structures in cells called 'nuclear speckles,' showing that they can work in partnership with a key protein to enhance the activities of specific sets of genes.



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Narcissism driven by insecurity, not grandiose sense of self

Narcissism is driven by insecurity, and not an inflated sense of self, finds a new study, which may also explain what motivates the self-focused nature of social media activity.



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Reading minds with ultrasound: A less-invasive technique to decode the brain's intentions

 

A new brain imaging application uses ultrasound to predict intended movements before they happen.



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Babies prefer baby talk, whether they're learning one language or two

A study finds babies prefer baby talk, whether they're learning one language or two. Scientists knew infants learning one language preferred the sing-song tones of parents' baby talk, and now scientists have found babies learning two languages are developmentally right on track. Bilingual babies showed the same interest in baby talk, at the same age, as monolingual babies.

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Starving tumors by blocking glutamine uptake

Scientists have identified a drug candidate that blocks the uptake of glutamine, a key food source for many tumors, and slows the growth of melanoma.


New study links protein causing Alzheimer’s disease with common sight loss

Newly published research has revealed a close link between proteins associated with Alzheimer’s disease and age-related sight loss. The findings could open the way to new treatments for patients with deteriorating vision and through this study, the scientists believe they could reduce the need for using animals in future research into blinding conditions.


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The Deadly Lung Disease You've Probably Never Heard Of

Pulmonary fibrosis is diagnosed in about 50,000 new patients annually, and as many as 40,000 Americans die from it each year 

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Double duty: Gut’s immune system helps regulate food processing, too

Yale researchers report the critical role played by the gut’s immune system in absorbing crucial nutrients to life and warding off life-threatening bacteria.




Exercise During Pregnancy May Save Kids From Health Problems as Adults

One day soon, a woman’s first trip to the doctor after conceiving may include a prescription for an exercise program.


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Forgotten Memories of Traumatic Events Get Some Backing from Brain-Imaging Studies

A new wave of research seeks neurological signatures for a type of amnesia 


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Is home screening a true colonoscopy alternative?

If you’re not eager to undergo the procedure, there are other colorectal cancer screening options. Yale Medicine experts explain.



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Researchers find a better way to measure consciousness

Millions of people are administered general anesthesia each year in the United States alone, but it’s not always easy to tell whether they are actually unconscious. A small proportion of those patients regain some awareness during medical procedures, but a new study of the brain activity that represents consciousness could prevent that potential trauma. 



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‘Leap forward’ in risk management of rectal cancer

Images from a probe, combined with deep learning, better differentiated residual cancerous tissue from recovered healthy tissue after chemoradiation treatment


Yale, VA researchers investigate eating disorders in veterans

Two new studies find that eating disorders — including atypical anorexia and binge-eating — are common among some veterans, offering guidance for treatment.


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Younger age of first cannabis use or prescription drug misuse is associated with faster development of substance use disorders

NIH analysis measures the prevalence of nine substance use disorders after first substance use or misuse in young people.


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Mayo Clinic Minute: Understanding chronic kidney disease

Chronic kidney disease is the gradual loss of kidney function. Some people, including African Americans, Native Americans and Asian Americans, are at higher risk of developing chronic kidney disease.


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Detecting cancer in the brain by scanning for salt

Yale scientists have devised a way to non-invasively locate tumors in the brain, by using an MRI scan to find where salt levels are imbalanced.



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Genetic therapies offer new hope against incurable brain diseases

Nature, Published online: 06 April 2021; doi:10.1038/d41586-021-00870-x A class of drugs that silence the effects of faulty genes could help tackle brain diseases — but a halted clinical trial has brought the field up short.



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Deactivating cancer cell gene boosts immunotherapy for head and neck cancers

The study, conducted in mice, opens a path for exploring treatments that combine epigenetic approaches with therapies that use the body’s natural immune response.



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What studies show about pregnancy, COVID-19 vaccines

A recent data review by the Advisory Committee on Immunization Practices shows that over 30,000 women who are pregnant have been safely vaccinated for COVID-19. The preliminary safety study, which took place between December 2020 and January 2021, compared women who were pregnant and not pregnant, and who received the Pfizer or Moderna COVID-19 vaccines. 


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Genetic testing proves beneficial in prescribing effective blood thinners

ROCHESTER, Minn. -- Pharmacogenomics is a valuable tool for health care providers to help prescribe the right drug for the right patient to enhance efficacy and avoid side effects.

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UCLA researchers digitize massive collection of folk medicine

UCLA Professor David Shorter’s Archive of Healing is one of the largest databases of medicinal folklore from around the world.

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Science Surgery: ‘Can cancers develop in the heart?’

Science blog Our Science Surgery series answers your cancer questions. Cancer can develop in nearly every organ in the body, including vital organs like the brain and lungs. As organs go, the heart is pretty vital – it’s basically one big muscle whose purpose is to pump blood around our bodies.

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Flu and Pneumonia Vaccines Lessen Risk of Alzheimer’s Disease

Most people only have to contract the flu once to be convinced that skipping a vaccination the next season isn’t a good idea. Cheers to those who choose to avoid the flu, or at least sidestep a full assault, by getting vaccinated before contracting and spreading it.

 

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