Redington Life Sciences News
 

August 2020

In this issue: tooth enamel at the atomic level, CD47 in the news again, the elusive tequila bat, Mayo on Covid-19, dissing raw milk, ultrasound and lethal brain cancer, making kidneys safe to transport, Dana-Farber on DNA repair, reversing age in animals, super bugs and the gut, and more…


Global wildlife surveillance could provide early warning for next pandemic

The virus that causes COVID-19 probably originated in wild bats that live in caves around Wuhan, China, and may have been passed to a second animal species before infecting people, according to the World Health Organization. Many of the most devastating epidemics of recent decades – including Ebola, avian influenza and HIV/AIDS – were triggered by animal viruses that spilled over into people.


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UVA IDs Gene Responsible for Deadly Glioblastoma

The discovery of the oncogene responsible for deadly glioblastoma could be the deadly cancer's Achilles' heel, one researcher says.


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The genetic basis of bats’ superpowers revealed

For the first time, the raw genetic material that codes for bats’ unique adaptations and superpowers such as the ability to fly, to use sound to move effortlessly in complete darkness, to survive and tolerate deadly diseases, to resist aging and cancer - has been fully revealed by an international research team including scientists at Bristol. The findings are published in Nature.


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Do Animals Really Anticipate Earthquakes? Sensors Hint They Do

Cows, sheep and dogs increased their activity before tremors, seemingly reacting in part to one another


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Gut bacteria protect against mosquito-borne viral illness

Chikungunya virus, once confined to the Eastern Hemisphere, has infected millions of people in the Americas since 2013, when mosquitoes carrying the virus were discovered in the Caribbean. About half of all people infected with chikungunya virus never show symptoms, while some develop fever and joint pain that lasts about a week, and 10% to 30% develop debilitating arthritis that persists


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Flu, Pneumonia Vaccinations Linked to Lower Alzheimer’s Risk, Researchers Say

Vaccines against the flu and pneumonia are associated with a lower risk of developing Alzheimer’s disease , while infections are generally linked to increased mortality among people with dementia, according to three research studies presented at this year’s Alzheimer’s Association International Conference , which is being held virtually this week. "With the COVID-19 pandemic, vaccines are at the


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uobA key gene modifies regulatory T cells to fine-tune the immune response

The human immune system is a finely-tuned machine, balancing when to release a cellular army to deal with pathogens, with when to rein in that army, stopping an onslaught from attacking the body itself. Now, researchers have discovered a way to control regulatory T cells, immune cells that act as a cease-fire signal, telling the immune system when to stand down.

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uobWhy it’s no last orders for the Tequila bat: DNA helps conservation of elusive bat

Scientists studying the ‘near threatened’ tequila bat, best known for its vital role in pollinating the Blue Agave plant from which the drink of the same name is made from, have analysed its DNA to help inform conservationists on managing their populations.


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fbioFortress Biotech Announces Publication of Study on Estimated Birth Prevalence of Menkes Disease in Molecular Genetics and Metabolism Reports

Cyprium Therapeutics, a Fortress partner company, is developing CUTX-101 for Menkes disease and is on track to begin submitting a rolling New Drug Application to the FDA in the fourth quarter of 2020

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yaleYale, Cambridge pioneer new way to make kidneys safe for transplant

A new drug regimen may undo the effects of cold storage that make human kidneys unsuitable for transplant.


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natureStructural cells are key regulators of organ-specific immune responses

Structural cells implement a broad range of immune-regulatory functions beyond their roles as barriers and connective tissues, and they utilize an epigenetically encoded potential for immune gene activation in their rapid response to viral infection.

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tgtxTG Therapeutics Completes Rolling Submission of New Drug Application to the U.S. Food and Drug Administration for Umbralisib as a Treatment for Patients with Previously Treated Marginal Zone Lymphoma or Follicular Lymphoma

TG Therapeutics, Inc., announced the completion of the rolling submission of a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) requesting accelerated approval of umbralisib, the Company’s investigational once-daily, oral, dual inhibitor of PI3K-delta and CK1-epsilon, as a treatment for patients with previously treated marginal zone lymphoma (MZL) and follicular lymphoma (FL).

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monashSuperbug impact on the gut

Monash University researchers discover how the bacterial superbug Clostridioides difficile hijacks the gut in order to cause serious and persistent disease

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uclaNearly 2 million California adults don’t get needed mental health care

A UCLA health policy brief recommends the expansion of Proposition 63 programs and services to address the unmet needs.

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AXSMAxsome Therapeutics Receives FDA Breakthrough Therapy Designation for AXS-05 for the Treatment of Alzheimer’s Disease Agitation

Designation offers potential for expedited development and review Axsome now granted two Breakthrough Therapy designations for AXS-05 for separate CNS indications

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nihComplexity of human tooth enamel revealed at atomic level in NIH-funded study

Unprecedented details of enamel structure may point to new ways to prevent or halt cavities.

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TNXPTonix Pharmaceuticals Plans Massachusetts R&D Facility to Accelerate Clinical Development of Vaccines and Protein-Based Therapeutics

Tonix's Advanced Development Center Will House Laboratories Dedicated to Process and Analytical Development

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uclaHow the body regulates scar tissue growth after heart attacks

A single protein may determine the size of scars, scientists say. Larger scars heighten the risk of future death from heart failure.

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nihNIH investigators hope CD47 study leads to broad-spectrum infectious diseases immunotherapy

Finding provides a potential target for an immunotherapy that might be applied to a wide range of infectious diseases.


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uvaFocused Ultrasound Shows Promise Against Deadliest Brain Tumor

Focused ultrasound waves create tiny bubbles inside cancer cells, causing them to die. The post appeared first on UVA Health Newsroom .

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ucamWomen who experience high blood pressure during pregnancy are more likely to develop heart disease

Between 1-6% of all pregnancies in Western countries are affected by high blood pressure, which usually returns to normal after giving birth. This condition is known as gestational hypertension, or pregnancy-induced hypertension. It differs from pre-eclampsia in that traces of protein are not found in the urine. Clinicians increasingly recognise that women who have had gestational hypertension


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crukNews digest – targeted drug approval, microbubble ‘warheads’ and prostate cancer treatment

Science blog With news about the coronavirus pandemic developing daily, we want to make sure everyone affected by cancer gets the information they need during this time. We’re pulling together the latest government and NHS health updates from across the UK in a separate blog post , which we’re updating regularly. Targeted drug to treat multiple cancer types approved in England A targeted cancer


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natureAn antiviral response beyond immune cells

Fibroblast, epithelial and endothelial cells are more than just the scaffold of an organ — it emerges that they communicate with immune cells and are primed to launch organ-specific gene-expression programs for antiviral defence.

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sdFemales use anti-inflammatory T cells to keep their blood pressure down

In the face of a multipronged front to drive blood pressure up, including a high-salt diet, females are better able to keep their pressure down by increasing levels of a T cell that selectively dials back inflammation, scientists say.


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ucdRaw milk may do more harm than good

Raw or unpasteurized cows' milk from U.S. retail stores can hold a huge amount of antimicrobial-resistant genes if left at room temperature, according to a new study.

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ucsdUniversal gut microbiome-derived signature predicts cirrhosis

Researchers report that stool microbiomes of NAFLD patients are distinct enough to potentially be used to accurately predict which persons with NAFLD are at greatest risk for having cirrhosis.

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ucbWhy do arteries age? Study explores link to gut bacteria, diet

Eat a slab of steak and your resident gut bacteria get to work immediately to break it down. But new research shows that a metabolic byproduct, called TMAO, produced in the process can be harmful to the lining of arteries, making them age faster.

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sdNew study examines recursive thinking

A multi-institutional research team found the cognitive ability to represent recursive sequences occurs in humans and non-human primates across age, education, culture and species.

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lsuNew class of safer analgesics discovered

Researchers have discovered a new class of pipeline drugs to relieve pain and reduce fever without the danger of addiction or damage to the liver or kidneys.

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sdNeurobiology: How much oxygen does the brain need?

The brain has a high energy demand and reacts very sensitively to oxygen deficiency. Neurobiologists have now succeeded for the first time in directly correlating oxygen consumption with the activity of certain nerve cells.

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uclaResearchers use stem cells to model the immune response to COVID-19

Two members of the UCLA Broad Stem Cell Research Center have received a grant for work that could be helpful in developing a vaccine.

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sdAge-related impairments reversed in animal model

Researchers demonstrate in an animal model that age-related frailty and immune decline can be halted and even partially reversed using a novel cell-based therapeutic approach.

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danaDrug with new approach on impeding DNA repair shows promise in first clinical trial

In its first randomized clinical trial, a drug that targets a protein needed by cancer cells to maintain their dogged growth and division has shown considerable promise in combination with chemotherapy in patients with a common form of ovarian cancer, investigators at Dana-Farber Cancer Institute report.

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uclaSome types of prostate cancer may not be as aggressive as originally thought

Research brief: Findings from a UCLA study indicate some men may not require the intensive treatment they have traditionally received.

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